The globalization of the economy creates new challenges for social work in the arenas of social and economic justice. This article outlines social justice issues related to the debt crisis of the Global South and sweatshops. A presentation of colonial precursors is followed by a detailed examination of these global institutions with an emphasis on the vulnerability, disempowered status, and exploitation of poor people of the Global South. Connections with global inequities in wealth, income, and the distribution of resources are made explicit. The article explores domestic social justice problems as possible points of connection with these issues. Finally, the authors give recommendations for social work education, advocacy, and activism.