Background: This study was conducted to determine the factors affecting the professionalism of human resources management in the Ministry of Industry, Mines, and Trade. Methods: A survey method was selected to collect data. We asked the managers of the Ministry of Industry, Mines, and Trade to answer the questionnaire. The statistical population included 165 vice presidents and heads of the Ministry of Mining Industry and Trade, who were selected by simple random sampling. The measurement tool was a Delphi questionnaire and researcher-made questionnaires. Reliability, convergent validity, and divergent validity of the data were tested. The relationship between the investigated variables was tested based on a causal structure with the partial least squares technique, and then the Goodness of fit (GOF) index was calculated. Results: The coefficient of determination of the endogenous structures of the research model was desirable. Moreover, the coefficient of determination of merit-oriented and health-oriented ministry creation was reported as 0.527 and 0.707, which were acceptable values. Also, cross-validity redundancy and commonality were obtained in the range of 0.15 to 0.35 ≥. Conclusion: The predictive power of the research constructs is estimated as a medium to strong.